Effect of Macrophages and Latent Reservoirs on the Dynamics of HTLV-I and HIV-1 Coinfection

Human immunodeficiency virus type 1 (HIV-1) and human T-lymphotropic I (HTLV-I) are two retroviruses that have a similar fashion of transmission via sharp objects contaminated by viruses, transplant surgery, transfusion, sexual relations. Simultaneous infections with HTLV-I HIV-1 usually occur in areas where both viruses become endemic. CD4+T cells the main targets HTLV-I, while can infect macrophages. It is aim this study to develop model coinfection describes interactions nine compartments: susceptible macrophages, HIV-1-infected latent/active HTLV-I-infected latent/active, free particles. The well-posedness, existence equilibria, global stability analysis our investigated. Lyapunov function LaSalle’s invariance principle were used asymptotic all equilibria. theoretically predicted outcomes verified utilizing numerical simulations. effect including macrophages latent reservoirs discussed. We show presence makes more realistic when case coexistence established. Moreover, we shown neglecting modeling will lead design an overflow anti-HIV-1 drugs.